IHC shows positive staining in paraffin-embedded human pancreas. Anti-Somatostatin Receptor 2 antibody was used at 1/250 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
Somatostatin Receptor 2 Recombinant Rabbit mAb (SDT-2507-1)
Somatostatin Receptor 2 Recombinant Rabbit mAb (SDT-2507-1)
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Product Details
Product Details
Product Specification
| Host | Rabbit |
| Antigen | Somatostatin Receptor 2 |
| Synonyms | Somatostatin receptor type 2; SS-2-R; SS2-R; SS2R; SST2; SRIF-1; SSTR2 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cell membrane |
| Accession | P30874 |
| Clone Number | SDT-2507-1 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | IHC-P, IF |
| Reactivity | Hu, Ms, Rt |
| Predicted Reactivity | Pg,Bv |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:250-1:1000 | Hu, Ms, Rt |
| IF | 1:100-1:500 | Hu, Ms |
Background
Somatostatin receptor 2 (SSTR2), encoded by the SSTR2 gene on chromosome 17q25.1, is a 369-amino-acid Gi-coupled class A G-protein-coupled receptor (GPCR) with seven transmembrane helices, extracellular N-glycosylation sites and intracellular phosphorylation motifs, existing as two splice variants (SST2A/B) with SST2A predominating in human tissues; it is highly expressed in brain and endocrine organs (pancreatic α/β-cells, pituitary somatotrophs) where it binds somatostatin-14/28 to inhibit adenylyl cyclase, voltage-gated Ca²⁺ channels and hormone secretion (e.g., glucagon, insulin, GH, TSH), and is widely over-expressed in neuroendocrine tumors, making it both a prognostic marker and a therapeutic target for radiolabeled peptides or selective agonists such as octreotide to suppress tumor growth and induce apoptosis .
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Immunohistochemistry
Negative control: IHC shows negative staining in paraffin-embedded human kidney. Anti-Somatostatin Receptor 2 antibody was used at 1/250 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
Negative control: IHC shows negative staining in paraffin-embedded human skeletal muscle. Anti-Somatostatin Receptor 2 antibody was used at 1/250 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded mouse pancreas. Anti-Somatostatin Receptor 2 antibody was used at 1/1000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded rat pancreas. Anti-Somatostatin Receptor 2 antibody was used at 1/1000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
Immunofluorescence
IF shows positive staining in paraffin-embedded human pancreas. Anti- Somatostatin Receptor 2 antibody was used at 1/100 dilution (Green) and incubated overnight at 4°C. Goat polyclonal Antibody to Rabbit IgG - H&L (Alexa Fluor® 488) was used as secondary antibody at 1/1000 dilution. Counterstained with DAPI (Blue). Heat mediated antigen retrieval with EDTA buffer pH9.0 was performed before commencing with IF staining protocol.
IF shows positive staining in paraffin-embedded mouse pancreas. Anti- Somatostatin Receptor 2 antibody was used at 1/500 dilution (Green) and incubated overnight at 4°C. Goat polyclonal Antibody to Rabbit IgG - H&L (Alexa Fluor® 488) was used as secondary antibody at 1/1000 dilution. Counterstained with DAPI (Blue). Heat mediated antigen retrieval with EDTA buffer pH9.0 was performed before commencing with IF staining protocol.
