Fc γ RIIB/CD32b His Tag Protein, Human
Fc γ RIIB/CD32b His Tag Protein, Human
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | Fc γ RIIb, CD32b;Fc gamma Receptor IIB/C, CD32, CD32b,CDw32 |
| Accession | P31994-1 |
| Amino Acid Sequence | Ala46-Pro217, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 27 -30 kDa(还原状态) |
| Purity | ＞98%, by SDS-PAGE under reducing conditions |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation . |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
Background
IgG Fc receptor (Fc γ R) is a member of the Ig superfamily, which plays a role in activating or inhibiting immune response. Human Fc γ Rs is identified as three types: RI (CD64), RII (CD32) and RIII (CD16). Human Fc γ RII / CD32 has three genes, CD32A, B and C, respectively. CD32 is a low affinity Fc receptor. Low-affinity immunoglobulin Fc γ region receptor II-b, namely CD32b, also known as FCGR2B, FCG2, IGFR2. CD32b was expressed on B cells and myeloid dendritic cells. The co-junction of CD32b on dendritic cells inhibits maturation and prevents cell activation. CD32b may also be a target for monoclonal antibody therapy of malignant tumors.
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Bioactivity
Anti-His antibody Immobilized on CM5 Chip captured CD32b His Tag, Human (Cat. No. UA020003), can bind IgG1-Fc (UA050001) with an affinity constant of 14.9 μM as determined in SPR assay (Biacore T200).
SDS-PAGE
Fc γ RⅡb/CD32b His Tag, Human，1 μg on SDS-PAGE under reducing and Non-reducing condition. The purity is greater than 98%.
RP-HPLC
