2μg (R: reducing condition, N: non-reducing condition).
Serpin G1/C1 Inhibitor His Tag Protein, Human
Serpin G1/C1 Inhibitor His Tag Protein, Human
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | SERPING1, C1IN, C1-INH, C1IN, HAE1, HAE2 |
| Accession | P05155-1 |
| Amino Acid Sequence | Asn23-Ala500 with His Tag at C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 85-100kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE &＞90% by SEC-HPLC |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Mahajan SD, Aalinkeel R, Reynolds JL, Machhar JS, Ghebrehiwet B, Schwartz SA. Omics analysis reveals galectin-3 to be a potential key regulator of allergic inflammation in hereditary angioedema. J Allergy Clin Immunol Glob. 2024 Oct 18;4(1):100353. |
Background
Serpin G1, also known as C1-inhibitor (C1-INH), is a crucial regulator of the complement, coagulation, fibrinolytic, and contact systems. The levels of protease/C1-INH complexes in the blood correlate with the in vivo activation of these four cascade-like plasma enzyme systems. C1-INH inhibits the activated forms of C1r and C1s, which are part of the first complement component, thereby regulating complement activation. Synthesized in the liver, deficiencies in C1-INH are associated with hereditary angioneurotic edema (HANE).
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SDS-PAGE
SEC-HPLC
The purity of Serpin G1/C1 Inhibitor His Tag Protein, Human is more than 90% determined by SEC-HPLC.
