2e5 of transient transfected anti- CEACAM-5/CD66e ScFv CAR-293 cells were stained with 0.1ug PE-Labeled CEACAM-5/CD66e Fc&Avi Tag Protein, Human, (Cat. No. UA011285) and unlable respectively (Fig. C and B), and non-transfected 293 cells were used as a control (Fig. A). PE signal was used to evaluate the binding activity.
2e5 of transient transfected anti- CEACAM-5/CD66e ScFv CAR-293 cells were stained with isotype and Whitlow/218 Linker-Alexa Fluor® 488 (Fig. D and E). Alexa Fluor® 488 signal was used to evaluate the binding activity.
PE-Labeled CEACAM-5/CD66e Fc&Avi Tag Protein, Human
PE-Labeled CEACAM-5/CD66e Fc&Avi Tag Protein, Human
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Product Specification
| Species | Human |
| Synonyms | CEA Cell Adhesion Molecule 5,CEACAM5,Meconium antigen 100,CEA,Carcinoembryonic Antigen Related Cell Adhesion Molecule 5,Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5,Carcinoembryonic Antigen,CD66e Antigen,CD66e |
| Accession | P06731 |
| Amino Acid Sequence | Lys35-Ala685 with Human IgG1 Fc&Avi Tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 120-160kDa |
| Conjugation | PE |
| Tag | Avi Tag, Human IgG1 Fc |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, pH7.4 |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1、Hammarstrom S. (1999). The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues. Seminars in Cancer Biology. 9(2): 67-81. |
Background
The human CEA family has been fully characterized. It comprises 29 genes of which 18 are expressed; 7 belonging to the CEA subgroup and 11 to the pregnancy specific glycoprotein subgroup. CEA is an important tumor marker for colorectal and some other carcinomas. The CEA subgroup members are cell membrane associated and show a complex expression pattern in normal and cancerous tissues with notably CEA showing a selective epithelial expression. Several CEA subgroup members possess cell adhesion properties and the primordial member, biliary glycoprotein, seems to function in signal transduction or regulation of signal transduction possibly in association with other CEA sub-family members.
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