IGF-I Protein, Human
IGF-I Protein, Human
Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | Insulin-Like Growth Factor I,IGF-I,Mechano Growth Factor,MGF,Somatomedin-C,IGF1,IBP1 |
| Accession | QP05019 |
| Amino Acid Sequence | Gly49-Ala118 |
| Expression System | E.coli |
| Molecular Weight | Approximately 7.6 kDa, a single non-glycosylated polypeptide chain containing 70 amino acids. |
| Purity | ＞98% by SDS-PAGE or HPLC. |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | 20 mM PBS, pH 7.0. |
| Reconstitution | Before use this product, please read the direction below carefully. This vial must be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in a sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃. Further dilutions should be made in appropriate buffered solutions. |
| Stability & Storage | For long term storage, the product should be stored ≤ -20℃. |
Background
The insulin-like growth factors (IGFs) belonged to the insulin gene family, are mitogenic polypeptide growth factors that stimulate the proliferation and survival of various cell types including muscle, bone, and cartilage tissue in vitro. The IGFs are similar by structure and function to insulin, but have a much higher growth-promoting activity than insulin. IGF-1 is produced primarily by the liver as an endocrine hormone as well as in target tissues in a paracrine/autocrine fashion. The production of IGF-1 is stimulated by growth hormone (GH) and can be retarded by undernutrition, growth hormone insensitivity, lack of growth hormone receptors, or failures of the downstream signaling pathway post GH receptor including SHP2 and STAT5B. Mature human IGF-1 shares 94% and 96% aa sequence identity with mouse and rat IGF-1, respectively , and exhibits cross-species activity. Recombinant human IGF-1 is a non-glycosylated polypeptide chain containing 70 amino acids..
