Human SFTPA2 Protein, His Tag

Pulmonary Surfactant-Associated Protein A2 (SP-A2) is a critical component of pulmonary surfactant, a lipoprotein complex essential for reducing surface tension in the alveoli and preventing lung collapse. Encoded by the SFTPA2 gene, it is primarily synthesized and secreted by type II pneumocytes. SP-A2 is a collectin, characterized by its collagen-like domain and carbohydrate recognition domain, which enables its key role in innate host defense. It opsonizes pathogens, enhances phagocytosis by alveolar macrophages, and modulates inflammatory responses. Genetic variants in SFTPA2 are associated with susceptibility to respiratory diseases, including pulmonary fibrosis, respiratory distress syndrome, and increased risk of severe lung infections.