2μg（R: reducing conditions）
Human OSMR Protein, His Tag
Human OSMR Protein, His Tag
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | Oncostatin-M-specific receptor subunit beta, Interleukin-31 receptor subunit beta (IL-31 receptor subunit beta; IL-31R subunit beta; IL-31R-beta; IL-31RB), OSMRB |
| Accession | Q99650 |
| Amino Acid Sequence | Protein sequence (Q99650, Glu28-Ser739, with C-His Tag) ERLPLTPVSLKVSTNSTRQSLHLQWTVHNLPYHQELKMVFQIQISRIETSNVIWVGNYSTTVKWNQVLHWSWESELPLECATHFVRIKSLVDDAKFPEPNFWSNWSSWEEVSVQDSTGQDILFVFPKDKLVEEGTNVTICYVSRNIQNNVSCYLEGKQIHGEQLDPHVTAFNLNSVPFIRNKGTNIYCEASQGNVSEGMKGIVLFVSKVLEEPKDFSCETEDFKTLHCTWDPGTDTALGWSKQPSQSYTLFESFSGEKKLCTHKNWCNWQITQDSQETYNFTLIAENYLRKRSVNILFNLTHRVYLMNPFSVNFENVNATNAIMTWKVHSIRNNFTYLCQIELHGEGKMMQYNVSIKVNGEYFLSELEPATEYMARVRCADASHFWKWSEWSGQNFTTLEAAPSEAPDVWRIVSLEPGNHTVTLFWKPLSKLHANGKILFYNVVVENLDKPSSSELHSIPAPANSTKLILDRCSYQICVIANNSVGASPASVIVISADPENKEVEEERIAGTEGGFSLSWKPQPGDVIGYVVDWCDHTQDVLGDFQWKNVGPNTTSTVISTDAFRPGVRYDFRIYGLSTKRIACLLEKKTGYSQELAPSDNPHVLVDTLTSHSFTLSWKDYSTESQPGFIQGYHVYLKSKARQCHPRFEKAVLSDGSECCKYKIDNPEEKALIVDNLKPESFYEFFITPFTSAGEGPSATFTKVTTPDEHSS |
| Expression System | HEK293 |
| Molecular Weight | Predicted MW: 82.7 kDa Observed MW: 120-140 kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. |
Background
Oncostatin M-specific receptor subunit beta (OSMRβ) is a crucial signaling component for cytokines Oncostatin M (OSM) and interleukin-31 (IL-31). It does not function alone but forms complexes with other subunits: with glycoprotein 130 (gp130) for OSM signaling, and with the IL-31 receptor alpha for IL-31 signaling. This dual partnership allows OSMRβ to mediate a diverse range of biological processes, including inflammation, cell proliferation, differentiation, and apoptosis. Its signaling is notably implicated in the pathogenesis of various cancers, promoting tumor growth and metastasis. Furthermore, through its role in the IL-31 receptor, OSMRβ is a primary driver of pruritus (itch) in inflammatory skin conditions like atopic dermatitis, making it a significant therapeutic target.
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