Immobilized Human GFRAL Protein, His Tag at 2 μg/mL (100 μL/well) can bind GDF-15 Protein, Human, Fc Tag (Cat. No. UA040129) with EC50 of 3.3-3.9 ng/ml.
Human GFRAL Protein, His Tag
Human GFRAL Protein, His Tag
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$70 USD
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | GFRAL, C6orf144 |
| Accession | Q6UXV0 |
| Amino Acid Sequence | Protein sequence (Q6UXV0, Ser19-Glu351, with C-His Tag) SQTNNCTYLREQCLRDANGCKHAWRVMEDACNDSDPGDPCKMRNSSYCNLSIQYLVESNFQFKECLCTDDFYCTVNKLLGKKCINKSDNVKEDKFKWNLTTRSHHGFKGMWSCLEVAEACVGDVVCNAQLASYLKACSANGNPCDLKQCQAAIRFFYQNIPFNIAQMLAFCDCAQSDIPCQQSKEALHSKTCAVNMVPPPTCLSVIRSCQNDELCRRHYRTFQSKCWQRVTRKCHEDENCISTLSKQDLTCSGSDDCKAAYIDILGTVLQVQCTCRTITQSEESLCKIFQHMLHRKSCFNYPTLSNVKGMALYTRKHANKITLTGFHSPFNGE |
| Expression System | HEK293 |
| Molecular Weight | Predicted MW: 39.5 kDa Observed MW: 35-45 kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. |
Background
GFRAL is a receptor primarily expressed in the hindbrain and binds to the hormone GDF15. It plays a key role in metabolic regulation, mediating appetite suppression and body weight control in response to stress, inflammation, or disease. GFRAL activation triggers downstream signaling through the RET coreceptor, influencing energy homeostasis. Its association with GDF15 has made it a potential therapeutic target for obesity and metabolic disorders.
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Bioactivity
SDS-PAGE
2μg（R: reducing conditions）
