HB-EGF Protein, Mouse

Catalog Number: UA040252 Brand: UA BIOSCIENCE

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$144 USD

Size: 10μg 50μg 100μg 500μg 1mg

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Product Details

Product Specification

Species	Mouse
Synonyms	Proheparin-binding EGF-like growth factor (HB-EGF)
Accession	Q06186
Amino Acid Sequence	Asp63-Leu148
Expression System	E.coli
Molecular Weight	14kDa (Reducing)
Purity	＞95% by SDS-PAGE and HPLC
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Physical Appearance	Lyophilized powder
Storage Buffer	20mM Tris, 300mM NaCl, pH8.0, 1mM DTT
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	Cancer Metastasis Rev. 2018 Sep;37(2-3):385-395.

Background

Proheparin-binding EGF-like growth factor (HB-EGF), also known as DTR, DTS and HEGFL, is a 13-15kDa member of the EGF family of mitogens. It is expressed in macrophages, monocytes, endothelial cells and muscle cells. HB-EGF signals through the EGF receptor to stimulate the proliferation of smooth muscle cells, epithelial cells and keratinocytes. Compared to EGF, HB-EGF binds to the EGF receptor with a higher affinity and has been shown to be more mitogenic, likely due to its ability to bind to heparin and heparin sulfate proteoglycans. It has been shown to play a role in wound healing, cardiac hypertrophy and heart development and function. The transmembrane form of HB-EGF is the unique receptor for diptheria toxin and functions in juxtacrine signaling in cells. Both forms of HB-EGF participate in normal physiological processes and in pathological processes including tumor progression and metastasis, organ hyperplasia, and atherosclerotic disease. HB-EGF can bind two locations on cell surfaces, heparan sulfate proteoglycans and EGF-receptor effecting cell to cell interactions.