Measured in a cell proliferation assay FDC-P1 cells, the EC50 for this effect is less than 0.05ng/ml.
GM-CSF Protein, Rat
GM-CSF Protein, Rat
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Product Details
Product Details
Product Specification
| Species | Rat |
| Synonyms | Granulocyte-macrophage colony-stimulating factor, Colony-stimulating factor (CSF), GM-CSF |
| Accession | P48750 |
| Amino Acid Sequence | Ala18-Lys144 |
| Expression System | E.coli |
| Molecular Weight | 14.5 kDa (Reducing) |
| Purity | >95% by SDS-PAGE and HPLC. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 20mM Tris,100mM NaCl, pH8.0 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Cell Mol Immunol. 2021 Aug;18(8):2057-2058. Epub 2021 Jul 19. |
Background
Granulocyte-macrophage colony-stimulating factor (GM-CSF), which belongs to the colony-stimulating factor (CSF) superfamily and was originally identified as a hemopoietic growth factor, is mainly produced by lymphocytes and innate lymphoid cells. During inflammation, GM-CSF is principally produced by T helper (Th) cells and acts as a communication conduit between myeloid cells and tissue-invading lymphocytes. GM-CSF increased Treg numbers and its immunoregulatory activities that led directly to dopaminergic neuronal protection in the substantia nigra and striatum
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Bioactivity
SDS-PAGE
2μg (R: reducing condition, N: non-reducing condition).
RP-HPLC
>95% as determined by RP-HPLC.
