Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The EC50 for this effect is less than 2μg/mL.
GDF-5/BMP-14 Protein, Mouse
GDF-5/BMP-14 Protein, Mouse
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Product Details
Product Details
Product Specification
| Species | Mouse |
| Synonyms | Growth/differentiation factor 5; GDF-5; Bone morphogenetic protein 14 (BMP-14); |
| Accession | P43027 |
| Amino Acid Sequence | Ala376-Arg495 |
| Expression System | E.coli |
| Molecular Weight | 15 kDa (Reducing) |
| Purity | >95% by SDS-PAGE. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 50mM HAc, pH2.9 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Nature. 1994 Apr 14;368(6472):639-43. |
Background
Growth differentiation factor 5 (GDF-5), also known as bone morphogenetic protein 14 (BMP-14), is a member of the transforming growth factor beta (TGF-β) superfamily. It plays a crucial role in skeletal development and joint formation, as well as in the regulation of cell growth and differentiation. In mice, GDF-5/BMP-14 is essential for the proper development of bones, cartilage, and joints, and mutations in the GDF-5 gene have been associated with skeletal abnormalities and joint disorders. GDF-5/BMP-14 exerts its biological activities by binding to specific cell surface receptors and activating downstream signaling pathways that regulate gene expression and cellular functions involved in skeletal development and maintenance.
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Bioactivity
SDS-PAGE
2μg (R: reducing condition, N: non-reducing condition).
