Measured in a cell proliferation assay using NIH-3T3 mouse embryonic fibroblast cells. The EC50 this effect is less than 0.6 μg/ml in the presence of 1.5 μg/ml recombinant human Klotho β.
FGF-21 Protein, Human
FGF-21 Protein, Human
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Product Details
Product Details
Product Specification
| Species | Human |
| Antigen | FGF-21 |
| Synonyms | Fibroblast growth factor 21 |
| Accession | Q9NSA1 |
| Amino Acid Sequence | His29-Ser209 |
| Expression System | E.coli |
| Molecular Weight | 24kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 20mM Tris, 150mM NaCl, pH 8.0 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1. J Clin Invest. 2005 Jun;115(6):1627-35.Epub 2005 May 2. 2. Exp Gerontol. 2020 Oct 1;139:111022. |
Background
Fibroblast Growth Factor 21(FGF-21) is a member of the fibroblast growth factor (FGF) family and it is involved in the modulation of cell proliferation, growth, and differentiation as well as cell metabolism. This protein is a secreted endocrine factor that functions as a major metabolic regulator, and stimulates the uptake of glucose in adipose tissue. FGF21 binds to FGFR1c complexed with β-Klotho expressed in adipocytes to activate the canonical FGF signaling pathway (ERK1/2) and the AMPK/PGC1α pathway. Therefore, FGF-21 is being pursued as a therapeutic target for diabetes and obesity.
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Bioactivity
SDS-PAGE
1μg (R: reducing condition, N: non-reducing condition).
