IHC shows positive staining in paraffin-embedded human cerebral cortex. Anti-CA4 antibody was used at 1/250 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
CA4 Recombinant Rabbit mAb (S-2339-24)
CA4 Recombinant Rabbit mAb (S-2339-24)
Price:
Regular price
$100 USD
Regular price
Sale price
$100 USD
Unit price
per
For shipping services or bulk orders, you may request a quotation.
Secure checkout with
View full details
Product Details
Product Details
Product Specification
| Host | Rabbit |
| Antigen | CA4 |
| Synonyms | Carbonic anhydrase 4; Carbonate dehydratase IV; Carbonic anhydrase IV (CA-IV) |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | P22748 |
| Clone Number | S-2339-24 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | IHC-P |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:250 | Hu, Ms, Rt |
Background
Carbonic anhydrase IV (CA4) is a glycosylphosphatidylinositol-anchored membrane-bound zinc metalloenzyme that catalyzes the reversible hydration of CO₂ to bicarbonate and protons, playing a pivotal role in CO₂ and pH homeostasis across ocular, renal, pulmonary, and cerebrovascular endothelia; expressed abundantly on the luminal surface of capillaries and in the renal proximal tubule brush border, CA4 facilitates rapid CO₂ elimination, modulates cerebrovascular reactivity, and supports retinal photoreceptor function, with mutations linked to retinitis pigmentosa 17 and its pharmacological inhibition explored for glaucoma, altitude sickness, and edema therapy.
Picture
Picture
Immunohistochemistry
IHC shows positive staining in paraffin-embedded human kidney. Anti-CA4 antibody was used at 1/250 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human pancreatic cancer. Anti-CA4 antibody was used at 1/250 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded mouse skeletal muscle. Anti-CA4 antibody was used at 1/250 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded rat cardiac muscle Anti-CA4 antibody was used at 1/250 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
