Product Specification
| Species |
Human |
| Synonyms |
CD19,B4,CVID3,MGC12802 |
| Accession |
P15391-1 |
| Amino Acid Sequence |
Pro 20-Lys 291 with His Tag at C-Terminus |
| Expression System |
CHO |
| Molecular Weight |
40-45kDa (Reducing) |
| Conjugation |
Alexa Fluor® 647 |
| Tag |
His Tag |
| Physical Appearance |
Liquid |
| Storage Buffer |
PBS, pH7.4 |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles. |
| Reference |
1.Wang SY, An WH, Wang ZS, Wang WL, Zhang B, Xu KL, Guo SL, Gao M, Li B, Huang L, Tian HH, Guo WY, Wang HR. Incidentally cured psoriasis in a patient with refractory/relapsed diffuse large B-cell lymphoma receiving CD19 CAR-T cell therapy: a case report. Front Immunol. 2024 Oct 24; 15: 1418768. |
Background
CD19, also known as B-lymphocyte antigen or Cluster of Differentiation 19, is a single-pass type I membrane protein that contains two Ig-like C2-type (immunoglobulin-like) domains. It is expressed on follicular dendritic cells and B cells, being present from the earliest recognizable B-lineage cells during development to B-cell blasts, but is lost upon maturation to plasma cells. CD19 primarily functions as a B cell co-receptor in conjunction with CD21 and CD81. Upon activation, the cytoplasmic tail of CD19 becomes phosphorylated, leading to binding by Src-family kinases and recruitment of PI-3 kinase. Mutations in the CD19 gene are associated with severe immunodeficiency syndromes, characterized by diminished antibody production. CD19 has been shown to interact with CD81, CD82, Complement receptor 2, and VAV2.
