WB result of ADRB2 Recombinant Rabbit mAb
Primary antibody: ADRB2 Recombinant Rabbit mAb at 1/1000 dilution
Lane 1: mouse heart lysate 20 µg
Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
Predicted MW: 46 kDa
Observed MW: 46 kDa
ADRB2 Recombinant Rabbit mAb (S-2418-144)
ADRB2 Recombinant Rabbit mAb (S-2418-144)
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Product Details
Product Details
Product Specification
| Host | Rabbit |
| Antigen | ADRB2 |
| Synonyms | Beta-2 adrenergic receptor; Beta-2 adrenoreceptor (Beta-2 adrenoceptor); ADRB2R; B2AR |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | P07550 |
| Clone Number | S-2418-144 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | mouse heart, rat heart |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Ms, Rt |
| IHC-P | 1:1000 | Hu, Ms, Rt |
Background
The ADRB2 (β2-adrenergic receptor) is a 413-amino-acid G-protein-coupled receptor embedded in the plasma membrane of airway, vascular, and adipose tissues, where it binds epinephrine and norepinephrine to trigger intracellular signaling cascades via Gs-mediated adenylyl cyclase activation, elevating cAMP and PKA to relax bronchial and vascular smooth muscle, modulate lipolysis, and influence cardiac output; encoded on chromosome 5q31–32, ADRB2 is highly polymorphic—most notably the Arg16Gly and Gln27Glu variants that alter down-regulation and desensitization—making it a pharmacogenomic target for β2-agonists in asthma and COPD therapy, and its structure has been captured in both active and inactive conformations by X-ray crystallography, revealing the molecular basis of agonist efficacy, inverse agonism, and biased signaling exploited in modern drug design.
Picture
Picture
Western Blot
WB result of ADRB2 Recombinant Rabbit mAb
Primary antibody: ADRB2 Recombinant Rabbit mAb at 1/1000 dilution
Lane 1: rat heart lysate 20 µg
Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
Predicted MW: 46 kDa
Observed MW: 46 kDa
Immunohistochemistry
IHC shows positive staining in paraffin-embedded human stomach. Anti-ADRB2 antibody was used at 1/1000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human gastric cancer. Anti-ADRB2 antibody was used at 1/1000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded mouse stomach. Anti-ADRB2 antibody was used at 1/1000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded mouse cerebral cortex. Anti-ADRB2 antibody was used at 1/1000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded rat stomach. Anti-ADRB2 antibody was used at 1/1000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
