Invivo anti-mouse Ly6G/Ly6C (Gr-1)
Invivo anti-mouse Ly6G/Ly6C (Gr-1)
Product Details
Product Details
Product Specification
| Host | Rat |
| Antigen | mouse Ly-6G/Ly-6C (Gr-1) |
| Synonyms | Lymphocyte antigen 6G, Ly-6G.1 |
| Location | Cell membrane |
| Accession | P35461 |
| Clone Number | RB6-8C5 |
| Antibody Type | Recombinant mAb |
| Isotype | Rat IgG2b,k |
| Isotype Control | Invivo rat IgG2b isotype control, anti-keyhole limpet hemocyanin |
| Application | in vivo depletion of Gr-1+ myeloid cells |
| Reactivity | Ms |
| Purification | Protein G |
| Concentration | 5 mg/ml |
| Purity | >95% (Determined by SDS-PAGE) |
| Endotoxin | <1EU/mg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, containing no preservative |
| Stability & Storage |
2 to 8 °C for 2 weeks under sterile conditions; -20 °C for 3 months under sterile conditions; -80 °C for 24 months under sterile conditions. Please avoid repeated freeze-thaw cycles. |
Background
This antibody recognizes the same epitope as clone RB6-8C5.It recognizes strongly with mouse Ly6G and weakly with mouse Ly6C. Ly-6G protein is a GPI (glycosylphosphatidylinositol)-anchored protein. Ly6G is primarily expressed on monocytes, neutrophils, and T cells. It plays a crucial role in inhibiting antitumor efficacy and Tcell responses. Due to its specific expression on neutrophils, Ly6G has been widely used as a surface marker in flow cytometry, cell sorting, and immune phenotyping experiments. Unique expression of Ly6G in bone marrow indicates its involvement in hematopoietic microenvironment, potentially regulating the development or function of immune cells within the bone marrow niche.
