Invivo anti-mouse Ly6G/Ly6C (Gr-1) (S-R425)
Invivo anti-mouse Ly6G/Ly6C (Gr-1) (S-R425)
Product Details
Product Details
Product Specification
| Host | Rat |
| Antigen | Mouse Ly-6G/Ly-6C (Gr-1) |
| Synonyms | Lymphocyte antigen 6G, Ly-6G.1 |
| Location | Cell membrane |
| Accession | P35461 |
| Clone Number | S-R425 |
| Antibody Type | Recombinant mAb |
| Isotype | Rat IgG2b,k |
| Application | in vivo depletion of Gr-1+ myeloid cells |
| Reactivity | Ms |
| Purification | Protein G |
| Concentration | 5 mg/ml |
| Endotoxin | <1EU/mg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, containing no preservative |
| Stability & Storage |
2 to 8 °C for 2 weeks under sterile conditions; -20 °C for 3 months under sterile conditions; -80 °C for 24 months under sterile conditions.
Please avoid repeated freeze-thaw cycles.
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Background
This antibody recognizes the same epitope as clone RB6-8C5. Ly-6G protein is a GPI (glycosylphosphatidylinositol)-anchored protein. Ly-6G is primarily expressed on monocytes, neutrophils, and T cells. It plays a crucial role in inhibiting anti-tumor efficacy and T-cell responses. Due to its specific expression on neutrophils, Ly-6G has been widely used as a surface marker in flow cytometry, cell sorting, and immune phenotyping experiments. Unique expression of Ly-6G in bone marrow indicates its involvement in hematopoietic microenvironment, potentially regulating the development or function of immune cells within the bone marrow niche.
