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Lactylation Drives Tumor Immune Evasion
1. Literature Information This research elucidates a lactate–lactylation–METTL3–m6A–STAT3 signaling axis that remodels tumorinfiltrating myeloid cells and promotes immunosuppression, revealing a key mechanism of tumor immune escape. 2. Research Background Tumor...
Lactylation Drives Tumor Immune Evasion
1. Literature Information This research elucidates a lactate–lactylation–METTL3–m6A–STAT3 signaling axis that remodels tumorinfiltrating myeloid cells and promotes immunosuppression, revealing a key mechanism of tumor immune escape. 2. Research Background Tumor...
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Glycyllysine Modification Maintains Nuclear–ER Homeostasis
1. Literature Information This study reveals that glycyllysine modification is a versatile posttranslational modification regulating DNA damage response, telomere stability, endoplasmic reticulum (ER) ribosome quality control, ERassociated degradation and ERphagy....
Glycyllysine Modification Maintains Nuclear–ER Homeostasis
1. Literature Information This study reveals that glycyllysine modification is a versatile posttranslational modification regulating DNA damage response, telomere stability, endoplasmic reticulum (ER) ribosome quality control, ERassociated degradation and ERphagy....
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DNA Methylation: The Core of Epigenetic Research
1. Concept DNA methylation is a stable epigenetic modification that adds methyl groups to the 5carbon of cytosine (forming 5mC), mostly at CpG sites, without altering DNA sequence. It stably...
DNA Methylation: The Core of Epigenetic Research
1. Concept DNA methylation is a stable epigenetic modification that adds methyl groups to the 5carbon of cytosine (forming 5mC), mostly at CpG sites, without altering DNA sequence. It stably...
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Fumaroylation: A New Hub Linking Metabolism and Epigenetics
1. Concept Protein lysine fumaroylation is a novel posttranslational acylation modification where fumaroyl groups from TCA cycle intermediate fumarate are covalently attached to lysine residues. It acts as a molecular...
Fumaroylation: A New Hub Linking Metabolism and Epigenetics
1. Concept Protein lysine fumaroylation is a novel posttranslational acylation modification where fumaroyl groups from TCA cycle intermediate fumarate are covalently attached to lysine residues. It acts as a molecular...
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Selective Chemical Labeling of Protein Lysine Methacrylation
1. Literature Information This work reveals a photocatalytic thiol–Michael addition strategy for highly specific chemical labeling and proteomic identification of lysine methacrylation, a newly discovered acylation modification highly similar to...
Selective Chemical Labeling of Protein Lysine Methacrylation
1. Literature Information This work reveals a photocatalytic thiol–Michael addition strategy for highly specific chemical labeling and proteomic identification of lysine methacrylation, a newly discovered acylation modification highly similar to...
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Site‑Specific Antibodies Drive Targeted Protein Degradation
1. Literature Information This literature dissects innovative research on site‑specific antibody‑mediated targeted protein degradation, focusing on lysosome‑directed elimination of extracellular and membrane proteins via hepatocyte asialoglycoprotein receptor (ASGPR) and homogeneous...
Site‑Specific Antibodies Drive Targeted Protein Degradation
1. Literature Information This literature dissects innovative research on site‑specific antibody‑mediated targeted protein degradation, focusing on lysosome‑directed elimination of extracellular and membrane proteins via hepatocyte asialoglycoprotein receptor (ASGPR) and homogeneous...
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