PD-L1 His Tag Protein, Human // Olivia // do not delete

Product Specification

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The Abpromise guarantee

Abpromise™ guarantees the use of ab217344 in the following tested applications

The dilutions shown under the "Application Notes" section are recommended starting dilutions only; the actual optimal dilution/concentration should be determined by the user.

Function

Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.

Disease related

Defects in CD8A are a cause of familial CD8 deficiency (CD8 deficiency) [MIM:608957]. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections.

Sequence similarity

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Post-translational modification

All of the five most carboxyl-terminal cysteines form inter-chain disulfide bonds in dimers and higher multimers, while the four N-terminal cysteines do not.

Cellular localization

Secreted and Cell membrane.

Database Link

• Entrez Gene: 12525 Mouse
• SwissProt: P012731 Mouse
• Unigene: 1858 Mouse

To our knowledge, customized protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheet download