Flow cytometric analysis of U266B1 (Human multiple myeloma B lymphocyte) labelling Human CD269 antibody at 1/200 dilution (1 μg) / (Red) compared with a Mouse IgG2a, κ (Black) Isotype control and an unlabelled control (cells without incubation with primary antibody and secondary antibody) (Blue). Goat Anti - Mouse IgG Alexa Fluor® 647 was used as the secondary antibody.
Mouse Anti-Human CD269 Antibody (S-R559)
Mouse Anti-Human CD269 Antibody (S-R559)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD269 |
| Synonyms | Tumor necrosis factor receptor superfamily member 17; B-cell maturation protein; BCM; BCMA; TNFRSF17 |
| Location | Cell membrane |
| Accession | Q02223 |
| Clone Number | S-R559 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | U266B1 |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1:200 | Hu |
Background
CD269, also known as B-cell maturation antigen (BCMA) or tumor necrosis factor receptor superfamily member 17 (TNFRSF17), is a type III transmembrane receptor of the TNF-receptor superfamily encoded by the TNFRSF17 gene, expressed predominantly on mature B cells, plasmablasts, and plasma cells, where it binds ligands BAFF and APRIL to activate NF-κB and MAPK8/JNK pathways, thereby promoting B-cell survival, differentiation, and immunoglobulin production while playing a crucial role in autoimmune responses.
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