Mouse Anti-Human CD203c Antibody (S-2916)

CD203c, also known as ectonucleotide pyrophosphatase/phosphodiesterase-3 (E-NPP3), is a type II transmembrane protein belonging to the ectonucleotide pyrophosphatase/phosphodiesterase family. It is specifically expressed on basophil-committed progenitor cells and mature basophils, and to a lesser extent on tissue mast cells. CD203c is rapidly upregulated on the cell surface upon basophil activation, such as through cross-linking of the IgE receptor, making it a valuable activation marker for these cells. It plays a role in regulating the inflammatory response by hydrolyzing ATP, which helps suppress chronic allergic inflammation. Additionally, CD203c has been identified as a potential biomarker for basophilia in diseases like chronic myeloid leukemia (CML), where its expression levels correlate with disease severity and treatment response.