1μg (R: reducing condition, N: non-reducing condition).
NOTCH3 Fc Chimera Protein, Human
NOTCH3 Fc Chimera Protein, Human
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$256 USD
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | CADASIL; CASILneurogenic locus notch homolog protein 3; Notch (Drosophila) homolog 3; notch 3Notch homolog 3 (Drosophila); Notch homolog 3; Notch3; Notch-3 |
| Accession | Q9UM47 |
| Amino Acid Sequence | Ala40 - Glu467 with Human IgG1 Fc at C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 75-90kDa (Reducing) |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human IgG1 Fc |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
Background
Notch3 is one of the four mammalian Notch proteins that serve as signaling receptors and are involved in developmental patterning, cell fate decisions, and the regulation of cell survival and proliferation. Notch3 interacts with membrane-bound ligands Jagged1, Jagged2, and Delta1 to regulate cell fate determination. Upon ligand activation, the Notch intracellular domain (NICD) is released and forms a transcriptional activator complex with RBPJ/RBPSUH, which in turn activates genes within the enhancer of split locus. As a result, the activation of Notch3 can initiate differentiation, proliferation, and apoptotic programs.
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SDS-PAGE
SEC-HPLC
The purity of NOTCH3 Fc Chimera Protein, Human is more than 95% as determined by SEC-HPLC.
