Measured by its Immobilized Recombinant Mouse TL1A at 2μg/ml (100 μl/well) can bind Human TL1A Antibody (9H5). The ED50 of Human TL1A Antibody (9H5)is 1.73 ng/ml...
TL1A Protein, Mouse
TL1A Protein, Mouse
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Product Details
Product Details
Product Specification
| Species | Mouse |
| Synonyms | Tumor Necrosis Factor Ligand Superfamily Member 15; TNF Ligand-Related Molecule 1; Vascular Endothelial Cell Growth Inhibitor; TNFSF15; TL1; VEGI |
| Accession | AAV33431.1 |
| Amino Acid Sequence | Ile76-Leu252 |
| Expression System | E.coli |
| Molecular Weight | 19 KDa, reducing conditions |
| Purity | >95% by SDS-PAGE; >95% by SEC-HPLC. |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 20mM PB, 300mM NaCl, pH 7.0. |
| Reconstitution | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
Background
Tumor Necrosis Factor Ligand Superfamily Member 15 (TNFSF15) is a new member of the tumor necrosis factor family. TNFSF15 is predominantly an endothelial cell-specific gene, and recombinant TNFSF15 is a potent inhibitor of endothelial cell proliferation, angiogenesis and tumor growth. TNFSF15 exerts two activities on endothelial cells: early G1 arrest of G0/G1-cells responding to growth stimuli and programmed cell death of proliferating cells. These activities are highly specific to endothelial cells. TNFSF15 is also able to regulate the expression of several important genes involved in angiogenesis. These findings are consistent with the view that TNFSF15 functions as an autocrine cytokine to inhibit angiogenesis and stabilize the vasculature.
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SDS-PAGE
SEC-HPLC
ELISA
