2μg (R: reducing condition, N: non-reducing condition).
IL-20 Protein, Human
IL-20 Protein, Human
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | Interleukin-20; IL-20; Cytokine Zcyto10; |
| Accession | Q9NYY1 |
| Amino Acid Sequence | Leu25-Glu176 |
| Expression System | E.coli |
| Molecular Weight | 18 kDa (Reducing) |
| Purity | >95% by SDS-PAGE. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Annu Rev Immunol. 2011:29:71-109. |
Background
Interleukin-20 (IL-20) is a member of the IL-10 cytokine family that plays a role in regulating inflammatory and immune responses. In humans, IL-20 is produced by activated monocytes, keratinocytes, and other cell types in response to pro-inflammatory stimuli. IL-20 signals through a receptor complex composed of IL-20R1 and IL-20R2 subunits, leading to the activation of downstream signaling pathways, including the JAK-STAT pathway. IL-20 has been implicated in various inflammatory conditions, including psoriasis, rheumatoid arthritis, and inflammatory bowel disease. It exerts its biological effects by promoting the production of pro-inflammatory cytokines, chemokines, and matrix metalloproteinases, contributing to tissue inflammation and remodeling.
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