2μg (R: reducing condition, N: non-reducing condition).
IL-17F Protein, Mouse
IL-17F Protein, Mouse
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Product Details
Product Details
Product Specification
| Species | Mouse |
| Synonyms | IL-17F,Interleukin-17F,Cytokine ML-1, |
| Accession | Q7TNI7 |
| Amino Acid Sequence | Arg29-Ala161 |
| Expression System | HEK293 |
| Molecular Weight | 17-24 kDa (Reducing) |
| Purity | >95% by SDS-PAGE and HPLC. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Immunity. 2019 Apr 16;50(4):892-906. |
Background
Interleukin-17F (IL17F) is also known as Interleukin-24 (IL24), Cytokine ML-1, is a secreted disulfide-linked homodimer which belongs to the IL-17 family. There are at least six members of the IL-17 family in humans and in mice: IL-17A, IL-17B, IL-17C, IL-17D, IL-17E (also called IL-25) and IL-17F (also called IL-24). IL-17 represents a family of structurally related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. IL-17F / IL-24 is expressed in activated, but not resting, CD4+ T-cells and activated monocytes. IL17F / Interleukin-24 stimulates the production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. IL17F / IL-24 stimulates PBMC and T-cell proliferation and Inhibits angiogenesis. Defects in IL17F are the cause of familial candidiasis type 6 (CANDF6).
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SDS-PAGE
SEC-HPLC
>95% as determined by SEC-HPLC.
RP-HPLC
>95% as determined by RP-HPLC.
SPR
Anti-His antibody Immobilized on CM5 Chip captured IL-17 RA Protein, Human (Cat. No. UA040024), can bind IL-17F Protein, Mouse (Cat. No. UA040476) with an affinity constant of 4.331μM as determined in SPR assay.
