2μg (R: reducing condition, N: non-reducing condition).
IL-12/IL-23 p40 Monomer Protein, Mouse
IL-12/IL-23 p40 Monomer Protein, Mouse
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Product Details
Product Details
Product Specification
| Species | Mouse |
| Synonyms | Interleukin-12 subunit beta,IL-12B,Cytotoxic lymphocyte maturation factor 40 kDa subunit (CLMF p40),IL-12 subunit p40 |
| Accession | P43432 |
| Amino Acid Sequence | Met23-Ser335 |
| Expression System | HEK293 |
| Molecular Weight | 40-45 kDa (Reducing) |
| Purity | >95% by SDS-PAGE and HPLC. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Annu Rev Immunol. 1998:16:495-521. |
Background
Interleukin-12 (IL-12) is a heterodimeric cytokine composed of two disulfide-linked subunits, p35 and p40. It plays a crucial role in regulating immune responses, particularly in promoting the differentiation of T helper 1 (Th1) cells and enhancing the cytotoxic activity of natural killer (NK) cells. The p40 subunit is shared between IL-12 and IL-23, another important cytokine involved in immune regulation. In mice, IL-12 p40 is produced by various immune cells, including macrophages, dendritic cells, and B cells. The p40 subunit can also exist as a homodimer or monomer, which can act as an antagonist to IL-12.
The p40 subunit is a target for therapeutic interventions in autoimmune and inflammatory diseases. Monoclonal antibodies against IL-12 p40 have been developed to inhibit its activity and reduce inflammation. Also, IL-12 has potent antitumor activity by stimulating the immune system to attack cancer cells. Recombinant IL-12 or IL-12 vectors are being explored as potential cancer treatments.
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SDS-PAGE
SEC-HPLC
>95% as determined by SEC-HPLC.
ELISA
Immobilized IL-12/IL-23 p40 Monomer Protein, Mouse (Cat. No. UA040455) at 2.0μg/mL (100μL/well) can bind IL-12 R beta 1 Fc Chimera Protein, Human (Cat. No. UA010956) with EC50 of 0.06-0.17μg/mL.
