Measured by its ability to inhibit the proliferation of murine M1 cells. The EC50 for this effect is less than 1μg/ml.
gAcrp30/gAdiponectin Protein, Human
gAcrp30/gAdiponectin Protein, Human
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | Adiponectin; 30 kDa adipocyte complement-related protein; Adipocyte complement-related 30 kDa protein (ACRP30); Adipocyte, C1q and collagen domain-containing protein; Adipose most abundant gene transcript 1 protein; Gelatin-binding protein; |
| Accession | Q15848 |
| Amino Acid Sequence | Ala108-Asn244 |
| Expression System | E.coli |
| Molecular Weight | 17 kDa (Reducing) |
| Purity | >95% by SDS-PAGE and HPLC. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 20mM Tris, 200mM NaCl, pH8.0 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Nat Med. 2007 Mar;13(3):332-9. Epub 2007 Feb 1. |
Background
Globular adiponectin (gAcrp30), also known as globular adiponectin or gAdiponectin, is a biologically active form of the adipokine adiponectin that plays a key role in regulating metabolism, insulin sensitivity, and inflammation. In humans, adiponectin is predominantly produced by adipocytes and circulates in the bloodstream in different isoforms, including the globular form. gAcrp30 is generated by proteolytic cleavage of full-length adiponectin and exerts its biological effects by binding to adiponectin receptors, AdipoR1 and AdipoR2, leading to the activation of signaling pathways such as AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor alpha (PPAR-α). gAcrp30 has been shown to have anti-inflammatory, anti-diabetic, and cardioprotective properties, as well as the ability to regulate lipid metabolism and insulin sensitivity.
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Bioactivity
SDS-PAGE
2μg (R: reducing condition, N: non-reducing condition).
SEC-HPLC
>95% as determined by SEC-HPLC.
