Measured in a cell proliferation assay using Balb/c 3T3 mouse fibroblast cells. The EC50 for this effect is less than 3ng/mL.
FGF-5 Protein, Human
FGF-5 Protein, Human
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | Fibroblast growth factor 5; FGF-5; Heparin-binding growth factor 5 (HBGF-5); Smag-82; |
| Amino Acid Sequence | His21-Gly268 |
| Expression System | E.coli |
| Molecular Weight | 30 kDa (Reducing) |
| Purity | >95% by SDS-PAGE. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 20mM Tris, 500mM NaCl, 1mM DTT, pH8.0 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):19679-88. |
Background
Fibroblast Growth Factor 5 (FGF-5) is a member of the fibroblast growth factor (FGF) family, which plays a crucial role in various cellular processes, including cell proliferation, differentiation, and survival. FGF-5 is primarily known for its involvement in regulating hair growth and cycling. It is expressed in the hair follicles and acts as a negative regulator of hair follicle growth. FGF-5 signaling is essential for the transition between different phases of the hair growth cycle, including the growth phase (anagen), regression phase (catagen), and resting phase (telogen). Dysregulation of FGF-5 expression or activity has been linked to hair loss disorders, such as alopecia, highlighting its importance in hair follicle biology.
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Bioactivity
SDS-PAGE
2μg (R: reducing condition, N: non-reducing condition).
