FGF-1 Protein, Mouse

Catalog Number: UA040089 Reactivity: Mouse Conjugation: Unconjugated Brand: UA BIOSCIENCE

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$90 USD

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Product Details

Product Specification

Species	Mouse
Synonyms	FGF-1, Acidic fibroblast growth factor(aFGF), Heparin-binding growth factor 1(HBGF-1)
Accession	P61148
Amino Acid Sequence	Phe16-Asp155
Expression System	E.coli
Molecular Weight	17-18kDa
Purity	>95% by SDS-PAGE
Endotoxin	<1EU/μg
Conjugation	Unconjugated
Tag	No Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	20mM PB, 150mM NaCl, pH7.4
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1、Zakrzewska M. et al. (2008) FGF-1: from biology through engineering to potential medical applications. Crit Rev Clin Lab Sci. 45(1): 91-135. 2、Pye D A. et al. (2000) Regulation of FGF-1 mitogenic activity by heparan sulfate oligosaccharides is dependent on specific structural features: differential requirements for the modulation of FGF-1 and FGF-2. Glycobiology. 10(11): 1183-1192.

Background

Fibroblast growth factor 1 (FGF-1), known as acidic fibroblast growth factor (FGF-Acidic), is one of the best characterized members of the FGF superfamily. FGF-1 is a powerful mitogen exhibiting strong action on numerous different cell types. It plays a role in various stages of development and morphogenesis, as well as in angiogenesis and wound healing processes. FGF-1 is released extracellularly as a disulfide-linked homodimer and is stored in complex with extracellular heparan sulfate. The association of FGF-1 with heparan sulfate is a prerequisite for its subsequent interaction with FGF receptors. Ligation triggers receptor dimerization, transphosphorylation, and internalization of receptor/FGF complexes.