Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. The EC50 for this effect is less than 30ng/ml.
CNTF Protein, Mouse
CNTF Protein, Mouse
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Product Details
Product Details
Product Specification
| Species | Mouse |
| Synonyms | Ciliary neurotrophic factor |
| Accession | P51642 |
| Amino Acid Sequence | Ala2-Met198 |
| Expression System | E.coli |
| Molecular Weight | 23kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 1xPBS, 2mM TCEP, pH 7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Prog Retin Eye Res. 2012 Mar;31(2):136-51.Epub 2011 Dec 10. Eur Cytokine Netw. 2004 Jul-Sep;15(3):255-62. |
Background
Ciliary neurotrophic factor (CNTF) is one of the most studied neurotrophic factors for neuroprotection of the retina. It is a neuroprotective cytokine initially identified in chick embryo. It has been evaluated for the treatment of neurodegenerative diseases. CNTF also acts on non-neuronal cells such as oligodendrocytes, astrocytes, adipocytes and skeletal muscles cells.
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Bioactivity
SDS-PAGE
1μg (R: reducing condition, N: non-reducing condition).
