Betacellulin Protein, Human
Betacellulin Protein, Human
Price:
Regular price
$162 USD
Regular price
Sale price
$162 USD
Unit price
per
For shipping services or bulk orders, you may request a quotation.
Secure checkout with
View full details
Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | Betacellulin, BTC |
| Accession | P35070 |
| Amino Acid Sequence | Asp32-Tyr111 |
| Expression System | E.coli |
| Molecular Weight | 12-16kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1、Yamamoto K. et al. (2000) Recombinant human betacellulin promotes the neogenesis ofβ-Cells and ameliorates glucose intolerance in mice with diabetes induced by selective alloxan perfusion. Diabetes. 49(12): 2021-2027. |
Background
Betacellulin (BTC) is a member of the epidermal growth factor (EGF) family. Betacelluli is expressed in most tissues including kidney, uterus, liver and pancreas. It is also present in body fluids, including serum, milk, and colostrum. It is synthesized primarily as a transmembrane precursor, which is then processed to a mature molecule by proteolytic events. Betacellulin signals through the EGF receptor.
Picture
Picture
Bioactivity
Measured in a cell proliferation assay using Balb/c 3T3 mouse fibroblast cells. The EC50 for this effect is less than 1ng/ml.
SDS-PAGE
1μg (R: reducing condition, N: non-reducing condition).
