Skip to product information
1 of 1

Mouse Anti-Human TCR α/β Antibody (S-R686)

Mouse Anti-Human TCR α/β Antibody (S-R686)

Catalog Number: S0B5513 Application: FCM Reactivity: Human Conjugation: Unconjugated Brand: Starter
Price:
Regular price $100.00 USD
Regular price Sale price $100.00 USD
Size:
For shipping services or bulk orders, you may request a quotation.
Secure checkout with
View full details

Product Details

Product Specification


Host Mouse
Antigen TCR α/β
Synonyms α/β TCR; TCR α/β
Location Cell membrane
Accession P01848、 P01850
Clone Number S-R686
Antibody Type Mouse mAb
Application FCM
Reactivity Hu
Positive Sample Human PBMC
Concentration 2 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS pH7.4

Stability & Storage 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.

Dilution


application dilution species
FCM 1:200 Hu

Background

The T cell receptor (TCR) α and β proteins are essential components of the αβ T cell receptor, a heterodimeric surface protein expressed on T lymphocytes that recognizes antigenic peptides presented by major histocompatibility complex (MHC) molecules. The TCR α chain is encoded by the TRAC (T cell receptor alpha constant) and TRAV (T cell receptor alpha variable) genes, while the TCR β chain is encoded by the TRBC (T cell receptor beta constant) and TRBV (T cell receptor beta variable) genes, along with diversity (TRBD) and joining (TRBJ) segments, enabling extensive combinatorial diversity. Structurally, both chains consist of a variable (V) domain responsible for antigen recognition and a constant (C) domain that anchors the receptor to the cell membrane. The TCR αβ heterodimer associates with the CD3 complex (CD3γε, CD3δε, and CD247 ζζ) to form a functional TCR-CD3 signaling unit, which transmits activation signals upon peptide-MHC engagement. TCR β undergoes V(D)J recombination during thymic development, contributing to the receptor's antigen specificity, whereas TCR α lacks a D segment but still undergoes recombination for diversity. Mutations or dysregulation in TCR α/β genes can lead to immune disorders, including T cell malignancies and autoimmune diseases. TCR αβ T cells are critical for adaptive immunity, mediating responses against infections, tumors, and self-antigens in autoimmune conditions.

Picture

FC

Flow cytometric analysis of Human PBMC (human peripheral blood mononuclear cells) labelling TCR α/β antibody at 1/200 (1 μg) dilution/ (Right panel) compared with a Mouse IgG Isotype Control / (Left panel). Goat Anti-Mouse IgG DyLight™ 488 was used as the secondary antibody. Then cells were stained with CD19 - Brilliant Violet 421™ Antibody separately.

Customer Reviews

Be the first to write a review
0%
(0)
0%
(0)
0%
(0)
0%
(0)
0%
(0)