Mouse Anti-Human CD80 Antibody (S-3119)

CD80, also known as B7-1, is a co-stimulatory molecule expressed on antigen-presenting cells (APCs) such as dendritic cells, macrophages, and B cells. It plays a crucial role in the immune response by interacting with CD28 on T cells to provide a necessary co-stimulatory signal for T cell activation. Additionally, CD80 can bind to CTLA-4, an inhibitory receptor on T cells, which serves as a negative regulatory mechanism to control the extent of the immune response. This dual functionality highlights the importance of CD80 in both initiating and modulating immune reactions, making it a key target in immunotherapy research for conditions such as cancer and autoimmune diseases.