Flow cytometric analysis of Mouse CD205 expression on BALB/c mouse bone marrow. BALB/c mouse bone marrow was stained with Pacific Blue™ Rat Anti-Mouse Ly-6G/Ly-6C Antibody and either Alexa Fluor® 647 Rat IgG2a, κ Isotype Control (Left panel) or SDT Alexa Fluor® 647 Rat Anti-Mouse CD205 Antibody (Right panel) at 5μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
Alexa Fluor® 647 Rat Anti-Mouse CD205 Antibody (S-R673)
Alexa Fluor® 647 Rat Anti-Mouse CD205 Antibody (S-R673)
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Product Details
Product Details
Product Specification
| Host | Rat |
| Antigen | CD205 |
| Synonyms | Lymphocyte antigen 75; Ly-75; DEC-205; Ly75 |
| Location | Membrane |
| Accession | Q60767 |
| Clone Number | S-R673 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | BALB/c mouse bone marrow |
| Purification | Protein G |
| Concentration | 0.05mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
CD205, also known as DEC-205, is a type I C-type lectin receptor and a member of the macrophage mannose receptor family. It is primarily expressed on dendritic cells (DCs), cortical thymic epithelial cells, and some leukocyte sub-populations. This receptor is involved in antigen uptake, processing, and presentation, playing a crucial role in the immune system. CD205 has a unique pH-dependent conformational change, allowing it to efficiently capture and internalize antigens in an acidic environment. Due to its high antigen-presenting efficiency, CD205 is widely used in immunotherapy, particularly in the development of antiviral and antitumor vaccines.
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