Measured by its ability to induce IL-8 secretion in A431 human epithelial carcinoma cells. The ED50 for this effect is less than 10ng/ml.
IL-36β Protein, Human
IL-36β Protein, Human
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$196.00 USD
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | Il36β;Interleukin-36 beta; Interleukin-1 family member 8; IL-1F8; Fil1e; Il1f8; |
| Accession | Q9NZH7-2 |
| Amino Acid Sequence | Met1-Glu157 |
| Expression System | E.coli |
| Molecular Weight | 18kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 20mM Tris,50mM NaCl,pH8.0. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Arthritis Res Ther. 2006;8(3):R80. |
Background
Interleukin-36 is a pro-inflammatory cytokine which plays an important role in the pathophysiology of several diseases. IL-36α, IL-36β, and IL-36γ (formerly IL-1F6, IL-1F8, and IL-1F9) are IL-1 family members that signal through the IL-1 receptor family members IL-1Rrp2 (IL-1RL2) and IL-1RAcP. IL-36βactivates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. IL-36βare involved in a number of fundamental biological processes such as stimulating production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes, inducing expression of a number of antimicrobial peptides including beta-defensin 4 and beta-defensin 103 as well as a number of matrix metalloproteases , inducing the production of proinflammatory cytokines in bone marrow-derived dendritic cells (BMDCs), including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23, and activating p38 MAPK phosphorylation in BMDCs.
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Bioactivity
SDS-PAGE
1μg (R: reducing condition, N: non-reducing condition).
