Human YWHAE/14-3-3 epsilon Protein, His Tag

YWHAE, also known as 14-3-3ε, is a member of the highly conserved 14-3-3 protein family. These proteins function as key regulatory molecules by binding to phosphorylated serine and threonine residues on a vast array of client proteins. Through these interactions, YWHAE modulates critical cellular processes including signal transduction, cell cycle control, apoptosis, and metabolism. It acts as a molecular scaffold, influencing the activity, localization, and stability of its binding partners. Its gene location within the 17p13.3 chromosomal region implicates it in human diseases; deletions encompassing YWHAE are associated with Miller-Dieker syndrome, a severe neuronal migration disorder, highlighting its essential role in brain development. YWHAE is dysregulated in various cancers, underscoring its importance in cellular proliferation and survival pathways.