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FGF R3 (IIIc) Fc Chimera Protein, Human

FGF R3 (IIIc) Fc Chimera Protein, Human

Catalog Number: UA011374 Brand: UA BIOSCIENCE
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$245 USD
$245 USD
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Product Details

Product Specification


Species Human
Synonyms FGF R3C,CD333,FGFR-3,FGFR3,JTK4
Accession P22607-1
Amino Acid Sequence

Glu23-Gly375 with hIgG1 Fc Tag at the C-Terminus
Expression System HEK293
Molecular Weight

80-95kDa (Reducing)
Purity ＞95% by SDS-PAGE & > 80% by SEC-HPLC
Conjugation Unconjugated
Tag Human IgG1 Fc
Physical Appearance Lyophilized powder
Storage Buffer

PBS, PH7.4, 5% trehalose
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1.Li R, Linscott J, Catto JWF, Daneshmand S, Faltas BM, Kamat AM, Meeks JJ, Necchi A, Pradere B, Ross JS, van der Heijden MS, van Rhijn BWG, Loriot Y. FGFR Inhibition in Urothelial Carcinoma. Eur Urol. 2025 Feb;87(2):110-122.
2.Asada N, Tanaka Y, Hayashido Y, Toratani S, Kan M, Kitamoto M, Nakanishi T, Kajiyama G, Chayama K, Okamoto T. Expression of fibroblast growth factor receptor genes in human hepatoma-derived cell lines. In Vitro Cell Dev Biol Anim. 2003 Jul-Aug;39(7):321-8.

Background

FGFR (fibroblast growth factor receptor) is a class of transmembrane proteins that consist of three immunoglobulin-like domains, a transmembrane region, and an intracellular tyrosine kinase domain. They transmit signals through ligand-induced dimerization and autophosphorylation, regulating cell growth and differentiation. Clinically, particularly in the case of FGFR3, gene alterations, abnormal expression (such as upregulation in epithelial tumors), and its activation of the PLCγ signaling pathway are closely associated with tumor development and resistance to endocrine therapies (such as tamoxifen), making it an important therapeutic target for cancer treatment.

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SDS-PAGE

2μg (R: reducing condition, N:non-reducing condition).

SEC-HPLC

The purity of FGF R3 (IIIc) Fc Chimera Protein, Human is more than 80% determined by SEC-HPLC.