Flow cytometric analysis of Human CD160 expression on human PBMC (human peripheral blood mononuclear cells). Human PBMC were stained with APC Mouse Anti-Human CD56 and Alexa Fluor® 488 Mouse IgM, κ Isotype Control (Left panel) or SDT Alexa Fluor® 488 Mouse Anti-Human CD160 Antibody (Right panel) at 5 μl/test. Total viable cells, as determined by Fixable Viability Dye 452 (S0D0021), were used for analysis. Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.
Alexa Fluor® 488 Mouse Anti-Human CD160 Antibody (S-3866)
Alexa Fluor® 488 Mouse Anti-Human CD160 Antibody (S-3866)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD160 |
| Synonyms | CD160 antigen; Natural killer cell receptor BY55; BY55 |
| Location | Cell membrane |
| Accession | O95971 |
| Clone Number | S-3866 |
| Antibody Type | Mouse mAb |
| Isotype | IgM,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human PBMC |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD160 is a glycosylphosphatidylinositol-anchored cell surface receptor of the immunoglobulin superfamily, expressed on subsets of CD4⁺ and CD8⁺ T cells, γδ T cells, NK cells and NKT cells, that binds classical and non-classical MHC-I molecules (HLA-C, -A, -E, -F) and herpesvirus entry mediator (HVEM) to deliver potent inhibitory or activating signals depending on cellular context; engagement on CD8⁺ T cells triggers PI3K-dependent survival and cytotoxic granule release, whereas on NK cells it enhances cytotoxicity and IFN-γ production, and its soluble form (sCD160) generated by metalloprotease shedding acts as a decoy receptor that limits angiogenesis and tumor growth, making CD160 a key checkpoint regulator of antiviral, antitumor and autoimmune responses.
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