Flow cytometric analysis of C57BL/6 mouse peritoneal exudates cells labelling Mouse MERTK antibody at 1/200 (1 μg) dilution/ (Right panel) compared with a Rat IgG2a, κ Isotype Control / (Left panel). Goat Anti-Rat IgG Alexa Fluor® 647 was used as the secondary antibody. Cells were stained with F4/80 - FITC Antibody separately.
Rat Anti-Mouse MERTK Antibody (S-R603)
Rat Anti-Mouse MERTK Antibody (S-R603)
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Product Details
Product Details
Product Specification
| Host | Rat |
| Antigen | MERTK |
| Synonyms | Tyrosine-protein kinase Mer; Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK; Mer |
| Location | Cell membrane |
| Accession | Q60805 |
| Clone Number | S-R603 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse peritoneal exudates |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1:200 | Ms |
Background
MERTK, also known as MER proto-oncogene tyrosine kinase, is a receptor tyrosine kinase and a member of the TAM (TYRO3, AXL, MERTK) family. It plays crucial roles in various physiological processes, including cell survival, migration, differentiation, and the phagocytosis of apoptotic cells, a process known as efferocytosis. MERTK is expressed in multiple tissues, such as macrophages and retinal pigment epithelial cells, and is involved in regulating immune responses and maintaining tissue homeostasis. In the immune system, MERTK helps macrophages clear apoptotic cells and inhibits the innate immune response by activating STAT1, which induces the production of suppressors of cytokine signaling (SOCS1 and SOCS3). Abnormal expression of MERTK has been linked to several diseases, including retinitis pigmentosa and certain cancers, making it a potential therapeutic target in cancer treatment.
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