Flow cytometric analysis of C57BL/6 mouse bone marrow labelling Mouse CD117 antibody at 1/200 (1 μg) dilution/ (Right panel) compared with a Rat IgG2b, κ Isotype Control / (Left panel). Goat Anti-Rat IgG Alexa Fluor® 647 was used as the secondary antibody. Then cells were stained with CD11b - Brilliant Violet 421™ Antibody separately.
Rat Anti-Mouse CD117 Antibody (S-R681)
Rat Anti-Mouse CD117 Antibody (S-R681)
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Product Details
Product Details
Product Specification
| Host | Rat |
| Antigen | Mouse CD117 |
| Synonyms | Mast/stem cell growth factor receptor Kit; SCFR; Proto-oncogene c-Kit; Tyrosine-protein kinase Kit; Kit; Sl |
| Location | Cell membrane |
| Accession | P05532 |
| Clone Number | S-R681 |
| Antibody Type | Rat mAb |
| Isotype | IgG2b,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse bone marrow |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1:200 | Ms |
Background
CD117, also known as c-Kit, is a receptor tyrosine kinase involved in cell growth, survival, and differentiation. It is expressed on various cell types, including hematopoietic stem cells, mast cells, melanocytes, and interstitial cells of Cajal in the gastrointestinal tract. CD117 plays a critical role in normal development and immune function, and its dysregulation is associated with several diseases, including cancers such as gastrointestinal stromal tumors (GIST) and acute myeloid leukemia (AML). Additionally, CD117 is a marker for cancer stem cells in some solid tumors and is targeted in cancer therapies.
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