NT-proBNP, Human
NT-proBNP, Human
Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | NT-proBNP;BNF, BNP, brain type natriuretic peptide, Gamma-brain natriuretic peptide, natriuretic peptide B, natriuretic peptide precursor B, natriuretic peptides B, natriuretic protein, NPPB |
| Accession | P16860 |
| Amino Acid Sequence | HHHHHHHPLG SPGSASDLET SGLQEQRNHL QGKLSELQVE QTSLEPLQES PRPTGVWKSR EVATEGIRGH RKMVLYTLRA PR |
| Expression System | E.coli |
| Molecular Weight | 9.2 kDa |
| Purity | ＞95%, by SDS-PAGE under reducing conditions |
| Endotoxin | <0.2EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS (pH7.2) |
| Reconstitution | Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation . |
| Stability & Storage | · 12 months from date of receipt, -20 to -70 °C as supplied. |
Background
The N-terminal fragment of pro-brain natriuretic peptide (N-terminal-prohormone Brain Natriuretic Peptide, NT-proBNP), whose molecular weight is 8.5kDa, belongs to the natriuretic peptide family protein, also known as type B brain natriuretic peptide, which has the functions of natriuretic, diuretic, vasodilation and so on. NT-proBNP is mainly synthesized and secreted by ventricular myocytes. Cardiac dysfunction such as high ventricular load and increased wall tension are the main conditions for stimulating NT-proBNP secretion, and the intensity of these stimulating factors is proportional to the content of NT-proBNP. Therefore, NT-proBNP can reflect the changes of ventricular function with strong specificity and high sensitivity, is a very important clinical marker of heart failure, and plays an irreplaceable role in early heart failure screening, prognosis evaluation and so on.
Picture
Picture
SDS-PAGE
