1μg (R: reducing condition, N: non-reducing condition).
Fas Ligand/TNFSF6 His Tag Protein, Mouse
Fas Ligand/TNFSF6 His Tag Protein, Mouse
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$200 USD
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Product Details
Product Details
Product Specification
| Species | Mouse |
| Synonyms | CD95L，Fas ligand，SPA，FASLG，Soluble Fas ligand，sFasL，Receptor-binding FasL ectodomain，FasL ICD，TNFSF6，Apoptosis antigen ligand，Tumor necrosis factor ligand superfamily member 6，APL，CD178，Fas Ligand (TNF Superfamily， Member 6)，Fas Antigen Ligand，CD95 Ligand，CD95-L，APTL，Mutant Tumor Necrosis Factor Family Member 6，Apoptosis (APO-1) Antigen Ligand 1，CD178 Antigen，ALPS1B，TNLG1A，FasL，Fas Ligand Protein，SPPL2A-processed FasL form，APT1LG1，Tumor Necrosis Factor (Ligand) Superfamily， Member 6，Tumor Necros，TNFSF6 |
| Accession | P41047-1 |
| Amino Acid Sequence | Pro132-Leu279, with N-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 25-33kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Review Cell Death Differ . 2012 Jan;19(1):42-50. Epub 2011 Sep 30. |
Background
Fas Ligand (FasL), also known as CD178, CD95L, or TNFSF6, is a 40 kDa type II transmembrane member of the TNF superfamily of proteins. Fas Ligand itself transmits reverse signals that costimulate the proliferation of freshly antigen-stimulated T cells. Apoptosis triggered by Fas-Fas ligand binding plays a fundamental role in the regulation of the immune system. Its functions include: T-cell homeostasis, cytotoxic T-cell activity, immune privilege, maternal tolerance, tumor counterattack. Defective Fas-mediated apoptosis may lead to oncogenesis as well as drug resistance in existing tumors. Germline mutation of Fas is associated with autoimmune lymphoproliferative syndrome (ALPS), a childhood disorder of apoptosis.
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SDS-PAGE
ELISA
Immobilized Fas/TNFRSF6/CD95 Fc Chimera Protein, Rat (Cat. No. UA011038) at 10.0μg/mL (100μL/well) can bind Fas Ligand/TNFSF6 His Tag Protein, Mouse (Cat. No. UA011012) with EC50 of 0.29-0.39 μg/ mL.
