1μg (R: reducing condition).
ENPP3/CD203c Fc Chimera Protein, Mouse
ENPP3/CD203c Fc Chimera Protein, Mouse
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$256 USD
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Product Details
Product Details
Product Specification
| Species | Mouse |
| Synonyms | EC:3.1.4.1，E-NPP 3，PD-Ibeta，NPPase，CD203c，PDNP3，Phosphodiesterase I/nucleotide pyrophosphatase 3，Nucleotide diphosphatase，ENPP3，DJ914N13.3 (Phosphodiesterase I/Nucleotide Pyrophosphatase 3)，Phosphodiesterase-I Beta，Phosphodiesterase I Beta，CD203c Antigen，Gp130RB13-6，NPP3，B10，Ectonucleotide pyrophosphatase/phosphodiesterase family member 3，Ectonucleotide Pyrophosphatase/Phosphodiesterase 3，DJ1005H11.3 (Phosphodiesterase I/Nucleotide Pyrophosphatase 3)，EC:3.6.1.9 |
| Accession | Q6DYE8 |
| Amino Acid Sequence | Arg46-Ile874 with Human IgG1 Fc Tag at N-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 110-150kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE &＞90% by SEC-HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human IgG1 Fc |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Yao, Wang, Han et al.[J] J Transl Med. (2023) 21 (1), 594. |
Background
ENPP3 (CD203c, ENPP3) is a member of the human NPP (Nucleotide Pyrophosphatase/Phosphodiesterase) family. It is expressed in various organs, including on epithelial and mucosal surfaces, and is particularly notable on basophils and mast cells. NPP3 serves as a common marker for diagnosing allergen sensitivity by analyzing patient basophils using flow cytometry.
Basophils and mast cells play a role in mediating responses to certain pathogens as well as acute and chronic allergic reactions. Upon activation, these cells release ATP, which further stimulates them in an autocrine manner. The upregulation of NPP3 helps to degrade ATP and suppresses chronic allergic inflammation, without affecting the acute response.
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SDS-PAGE
SEC-HPLC
The purity of ENPP3/CD203c Fc Chimera Protein, Mouse is greater than 90% as determined by SEC-HPLC.
