2μg (R: reducing condition, N: non-reducing condition).
Collectrin/TMEM27 Fc Chimera Protein, Human
Collectrin/TMEM27 Fc Chimera Protein, Human
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | NX-17 Protein, Human; NX17 Protein, Human |
| Accession | Q9HBJ8 |
| Amino Acid Sequence | Glu15-Pro141, with C-hIgG1 Fc |
| Expression System | HEK293 |
| Molecular Weight | 53-60kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human Fc Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Acta Oncol . 2022 Dec;61(12):1507-1511.Epub 2022 Nov 11. |
Background
Transmembrane protein 27 (TMEM27/collectrin), a glycoprotein and homolog of angiotensin-converting enzyme 2 (ACE2), is a regulator of renal amino acid uptake in the proximal tubule and may have a protective role in hypertension.Mature human Collectrin consists of a 127 amino acid (aa) extracellular domain (ECD), a 21 aa transmembrane segment, and a 60 aa cytoplasmic domain. Collectrin is highly expressed in the proximal convoluted tubules of the renal collector and inhibits the proliferation of tubular epithelial cells.Collectrin is also expressed in pancreatic islet beta cells and enhances glucose‑stimulated insulin secretion as well as insulin resistance.
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