1μg (R: reducing condition, N: non-reducing condition).
ALPG His Tag Protein, Mouse
ALPG His Tag Protein, Mouse
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$276 USD
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Product Details
Product Details
Product Specification
| Species | Mouse |
| Synonyms | ALPG, GCAP, ALP-1, ALPPL2, PLAP-like, ALPPL, Alkaline phosphatase, germ cell type |
| Accession | P24823 |
| Amino Acid Sequence | Val19-Ser502 with His Tag at C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 60-72kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE &＞85% by SEC-HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Yang Su, et al. ALPPL2 Is a Highly Specific and Targetable Tumor Cell Surface Antigen. Cancer Res, 2020. |
Background
Alkaline phosphatase, placental-like 2 (ALPPL2, also known as ALPG) is a glycosylphosphatidylinositol (GPI)-anchored membrane protein and a member of the human alkaline phosphatase family. Typically not expressed in normal tissues except for the trophoblast, ALPPL2 shows a high tumor specificity. Immunohistochemical (IHC) analysis of tumor tissue arrays has revealed its expression in 43% of mesotheliomas, 60% of ovarian cancers, 36% of pancreatic cancers, 18% of gastric cancers, and 100% of seminomas.
ALPPL2 is not only a candidate for therapy development targeting ALPPL2-expressing tumors but has also been identified as a significant surface marker specific to the naive state of pluripotency, which is essential for both the establishment and maintenance of this state. Studies have demonstrated that the knockout of ALPPL2 can specifically impact the establishment, stability, and maintenance of naive pluripotency, confirming that the ALPPL2 protein is a functional molecular marker of the naive state surface.
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SDS-PAGE
SEC-HPLC
The purity of ALPG His Tag Protein, Mouse is greater than 85% as determined by SEC-HPLC.
