Product Details
Product Details
Product Specification
Host | Human |
Accession | P13612 |
Clone Number | S-SC023 |
Antibody Type | Recombinant mAb |
Isotype | IgG4,k |
Application | Blocking of Integrin alpha-4 signaling Functional assays |
Purification | Protein A |
Concentration | 2 mg/ml |
Endotoxin | <1EU/mg |
Conjugation | Unconjugated |
Physical Appearance | Liquid |
Storage Buffer | PBS pH7.4, containing no preservative |
Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Background
Natalizumab, is a monoclonal antibody which targets a protein called α4β1 integrin on white blood cells involved in inflammation. By attaching to integrin, natalizumab is thought to stop white blood cells from entering the brain and spinal cord tissue, thereby reducing inflammation and the resulting nerve damage.
