Multiparameter flow cytometric analysis of Human CD42b expression on human peripheral blood. Human peripheral blood was stained with Alexa Fluor® 647 Mouse Anti-Human CD41a antibody and SDT Alexa Fluor® 488 Mouse Anti- Human CD42b antibody at 2 μg/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
Alexa Fluor® 488 Mouse Anti-Human CD42b Antibody (S-935-7)
Alexa Fluor® 488 Mouse Anti-Human CD42b Antibody (S-935-7)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD42b |
| Synonyms | GPIb; Platelet glycoprotein Ib alpha chain; GPIb-alpha; GPIbA; Glycoprotein Ibalpha; Antigen CD42b-alpha |
| Immunogen | Recombinant Protein |
| Location | Membrane |
| Accession | P07359 |
| Clone Number | S-935-7 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human peripheral blood |
| Purification | Protein G |
| Concentration | 0.4 mg/ml |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5 μl per million cells in 100μl volume | Hu |
Background
Platelet glycoprotein Ib alpha chain also known as glycoprotein Ib (platelet), alpha polypeptide or CD42b (Cluster of Differentiation 42b), is a protein that in humans is encoded by the GP1BA gene. Glycoprotein Ib (GPIb) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that are linked by disulfide bonds. The GpIb functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V to form the glycoprotein Ib-IX-V complex. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis.
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