Flow cytometric analysis of BALB/c mouse Peripheral Blood cells labelling Mouse CD193 Antibody at 1/2000 dilution (0.1 μg) / (Right panel) compared with a Rat IgG2a, κ Isotype Control / (Left panel). Goat Anti-Rat IgG Alexa Fluor® 488 was used as the secondary antibody. Then cells were stained with Ly6G/Ly6C - Pacific Blue™ Antibody separately.
Rat Anti-Mouse CD193 Antibody(S-R699)
Rat Anti-Mouse CD193 Antibody(S-R699)
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Product Details
Product Details
Product Specification
| Host | Rat |
| Antigen | CD193 |
| Synonyms | Probable C-C chemokine receptor type 3; C-C CKR-3; CC-CKR-3; CCR-3; CCR3; CKR3; Macrophage inflammatory protein 1-alpha receptor-like 2 (MIP-1 alpha RL2); Cmkbr1l2; Cmkbr3 |
| Location | Cell membrane |
| Accession | P51678 |
| Clone Number | S-R699 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | BALB/c mouse Peripheral Blood cells |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1:2000 | Ms |
Background
CD193, also known as C-C motif chemokine receptor 3 (CCR3), is a member of the G protein-coupled receptor (GPCR) family, characterized by its seven-transmembrane structure. It is a high-affinity receptor for various chemokines, including eotaxin-1 (CCL11), eotaxin-2 (CCL24), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). CD193 is highly expressed on eosinophils, basophils, and airway epithelial cells, and is also detected in CD4+ T cells, mast cells, monocytes, platelets, and CD34+ hematopoietic progenitor cells. This receptor plays a crucial role in mediating the migration and activation of eosinophils and other inflammatory cells, contributing to allergic responses and inflammatory processes in conditions such as asthma and allergic rhinitis. Additionally, CD193 has been identified as a co-receptor for HIV-1 entry into cells.
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