CD73 Mouse mAb (S-715-115)

Catalog Number: S0B0455 Application: FCM Reactivity: Human Conjugation: Unconjugated Brand: Starter

Price:

$130.00 SGD

Size: 25μl 100μl

Quantity:

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Product Details

Product Specification

Host	Mouse
Antigen	CD73
Synonyms	5'-nucleotidase, 5'-NT, 5'-deoxynucleotidase, Ecto-5'-nucleotidase, IMP-specific 5'-nucleotidase, Thymidylate 5'-phosphatase, NT5E, NT5, NTE
Immunogen	Recombinant Protein
Location	Cell membrane
Accession	P21589
Clone Number	S-715-115
Antibody Type	Mouse mAb
Isotype	IgG2b,k
Application	FCM
Reactivity	Hu
Purification	Protein A
Concentration	2 mg/ml
Conjugation	Unconjugated
Physical Appearance	Liquid
Storage Buffer	PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage	12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution

application	dilution	species
FCM	1:5000	null

Background

NT5E (CD73) is a surface enzyme which is expressed on multiple cells. This enzyme mediates the gradual hydrolysis of the autocrine and paracrine danger signals of ATP and ADP to anti-inflammatory adenosine. Immune suppression mediated by adenosinergic pathways is very important for maintaining immune system homeostasis. Immune suppressive functions of T regulatory cells are also dependent on CD73 expression. CD73 also occurs on anergic CD4 + T cells, thereby maintaining self-tolerance to healthy tissues as well as protecting the fetus from the mother's immune system during pregnancy.

Picture

FC

Flow cytometric analysis of human PBMC (human peripheral blood mononuclear cell) labelling CD73 antibody at 1/5000 (0.04 μg) dilution (Right) compared with a Mouse monoclonal IgG isotype control (Left). Goat Anti - Mouse IgG Alexa Fluor® 488 was used as the secondary antibody. Then cells were stained with CD3 - Alexa Fluor® 647 separately. Events were gated on viable lymphocytes.

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CD73 Mouse mAb (S-715-115)