IHC shows positive staining in paraffin-embedded human tonsil. Anti-CD57 antibody was used at 1/500 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
CD57 Mouse mAb (S-R571)
CD57 Mouse mAb (S-R571)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD57 |
| Synonyms | Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1; Beta-1,3-glucuronyltransferase 1; Glucuronosyltransferase P (GlcAT-P); UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase (GlcUAT-P); B3GAT1; GLCATP; HNK-1; Leu-7 |
| Location | Golgi apparatus membrane |
| Accession | Q9P2W7 |
| Clone Number | S-R571 |
| Antibody Type | Mouse mAb |
| Application | IHC-P |
| Reactivity | Hu |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:500 | Hu |
Background
CD57 (also known as HNK-1 or LEU-7) is an 110 kDa glycoprotein predominantly expressed on natural killer (NK) cells, terminally differentiated CD8+ T cells, some monocytes, and neural crest cells. In the immune system, CD57 expression is associated with cellular senescence and terminal differentiation, characterized by reduced proliferative capacity but enhanced cytotoxicity. In NK cells, CD57 marks a more mature phenotype with higher cytotoxicity and responsiveness to signals from CD16 and natural cytotoxicity receptors (NCRs). Additionally, CD57 plays a role in the nervous system, where it is involved in neural crest cell migration and invasion, and is associated with metastasis in melanoma. Clinically, CD57 is used as a diagnostic marker for neuroendocrine and nervous system tumors.
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Immunohistochemistry
IHC shows positive staining in paraffin-embedded human stomach. Anti-CD57 antibody was used at 1/500 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human thyroid cancer. Anti-CD57 antibody was used at 1/500 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human ovarian cancer. Anti-CD57 antibody was used at 1/500 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
